10 The Mantel–Haenszel procedure

Mantel and Haenszel (1959) proposed, for case-control studies of cancer stratified by age and other factors, a summary odds ratio and a test of association that need no iteration, tolerate empty cells and remain valid when the strata are many and small. Their methods, extended since to risk ratios, risk differences and rate ratios, are the standard tools of stratified analysis. Throughout, stratum \(k\) has the table of Section 4 with cells \(a_k, b_k, c_k, d_k\), margins \(n_{1k}, n_{0k}, m_{1k}, m_{0k}\) and total \(n_k\).

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