12.3 Review: which method for which question

Table 2 collects the methods of the course by the question they answer. Three habits run through all of them: account for censoring rather than discarding it; state what the time origin and the event are; and check the assumptions of a model, proportional hazards above all, before reporting its single summary numbers.

Question Method In R
What fraction survive to \(t\)? Kaplan–Meier, Greenwood (Section 4) survfit
What is the cumulative risk? Nelson–Aalen, life tables (Section 5) survfit
A smooth model, extrapolation Weibull and others (Section 3) survreg
Do groups differ? log-rank tests (Section 6) survdiff
Covariate effects on the hazard Cox model (Sections 7 and 8) coxph
Is the hazard ratio constant? Schoenfeld residuals (Section 9) cox.zph
Effects on time; predictions AFT models (Section 10) survreg
Several kinds of event incidence, Fine–Gray (Section 11) survfit, finegray
Clusters, repeated events frailty, Andersen–Gill (Section 11) frailty, cluster
How many patients? Schoenfeld’s formula (Section 12) simulation
Table 2: The methods of the course, by question.

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